The KRAS Mutation is Highly Correlated With EGFR Alterations in Patients With Non-small Cell Lung Cancer

Received 1 October 2009; received in revised form 26 October 2009; accepted 30 October 2009.

To understand epidermal growth factor receptor (EGFR) and KRAS alterations among tissues of lung cancer patients in Taiwan, and to further understand how they are related, we used tumor tissues from the non-small cell lung cancer patients and performed a complete analysis. In the experimental results, coexisting EGFR and KRAS mutations were found in 1% (2/180) of the samples. This shows that these mutations tend not to coexist. Furthermore, nearly no coexistence was found between KRAS mutations and EGFR overexpression. These outcomes greatly assist the efficacy prediction of current anti-EGFR drugs for cancer patients.

Key Words: EGFR , KRAS , non-small cell lung cancer

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a Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

b Department of Orthopedic Surgery, Pingtung Christian Hospital, Pingtung, Taiwan

c School of Medical and Health Science, Fooyin University, Kaohsiung, Taiwan

d Department of Medical Research, Fooyin University Hospital, Pingtung, Taiwan

e School of Environmental and Life Sciences, Fooyin University, Kaohsiung, Taiwan

f Technology Development Center of Molecular Diagnosis and Fermentation Engineering, Fooyin University, Kaohsiung, Taiwan

g Department of Chest Medicine, Fooyin University Hospital, Pingtung, Taiwan

h Gene Target Technology Co. Ltd., Kaohsiung, Taiwan

i Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

Corresponding authors. Jaw-Yuan Wang: Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 100 Tzyou 1st Road, Kaohsiung 807, Taiwan. Shiu-Ru Lin: School of Medical and Health Sciences, Fooyin University, 151 Chin-Hsueh Road, Ta-Liao Hsiang, Kaohsiung 831, Taiwan

† Ming-Je Yang and Chi-Kuei Hsu contributed equally to this work.

PII: S1877-8607(10)60002-1

doi:10.1016/S1877-8607(10)60002-1

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